|
KMID : 1123920030170010140
|
|
Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 1 p.140 ~ p.145
|
|
|
Effects of the Fermented Extract Using the Leaves of Pinus densiflora on Hyperlipidemia Rats
|
|
Kang Dae-Gill
Lee Yun-Mi
Oh Hyun-Cheol
Mun Yeun-Ja
Lee Ho-Sub
Woo Won-Hong
|
|
|
Abstract
|
|
|
|
The present study was designed to examine whether the fermented extract using the leaves of Pinus densiflora (FPD), has an ameliorative effect on the lipid metabolism in rats with hyperlipidemia. The body weight gain was attenuated by the adminstration of either 1-dose (2 ml/kg/day) or 2-dose (4 ml/kg/day) of FPD for 2 weeks compared with that of control or hyperlipidemia rats, while blood glucose, systolic blood pressure, sGOT, and sGPT were not altered. Serum total cholesterol, LDL-cholesterol, and athelosclerotic index were partially restored by the administration of 2-dose of FPD in rats with hyperlipidemia without changes of serum HDL-cholesterol, total lipid, and triglyceride concentration. The FPD also partially ameliorated renal functional parameters including plasma cleatinine and creatinine clearance which were attenuated in rats with hyperlipidemia. These results suggest that FPD has an ameliorative effect on the lipid metabolism and renal function in rats with hyperlipidemia.
|
|
|
KEYWORD
|
|
|
Pinus densiflora, hyperlipidemia, cholesterol, creatinine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|